Cheracol Plus

Generic Name: chlorpheniramine/dextromethorphan/phenylpropanolamine (klor fen IR a meen/dex troe meth OR fan/fen ill proe pa NOLE a meen)

Brand Names: Cheracol Plus, Kophane, Therahist, Threamine DM, Triaminicol Multi Symptom Cough and Cold, Tricodene Forte, Tricodene NN, Triphenicol

What is Cheracol Plus (chlorpheniramine/dextromethorphan/phenylpropanolamine)?

Chlorpheniramine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in the body. Chlorpheniramine prevents sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Dextromethorphan is a cough suppressant. It suppresses an area in the brain that causes coughing.

Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces the blood flow and allows nasal and respiratory (breathing) passages to open up.

Chlorpheniramine/dextromethorphan/phenylpropanolamine is used to treat nasal congestion, sinusitis (inflammation of the sinuses), and coughs associated with allergies, hay fever, and the common cold.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Chlorpheniramine/dextromethorphan/phenylpropanolamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Cheracol Plus (chlorpheniramine/dextromethorphan/phenylpropanolamine)?

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Use caution when driving, operating machinery, or performing other hazardous activities. Chlorpheniramine/dextromethorphan/phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking chlorpheniramine/dextromethorphan/phenylpropanolamine.

Do not take more of this medication than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor.

Who should not take Cheracol Plus (chlorpheniramine/dextromethorphan/phenylpropanolamine)?

Do not take chlorpheniramine/dextromethorphan/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

• kidney disease,


• liver disease,


• 
  

  diabetes,

  
  


• 
  

  glaucoma,

  
  


• 
  

  any type of heart disease or high blood pressure,

  
  


• 
  

  thyroid disease,

  
  


• 
  

  emphysema or chronic bronchitis, or

  
  


• 
  

  difficulty urinating or have an enlarged prostate.

  
  

You may not be able to take chlorpheniramine/dextromethorphan/phenylpropanolamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether chlorpheniramine/dextromethorphan/phenylpropanolamine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. This medication passes into breast milk and may harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from chlorpheniramine/dextromethorphan/phenylpropanolamine. You may require a lower dose of this medication. Read the package label for directions or consult your doctor or pharmacist before treating a child with this medication. Children are more susceptible than adults to the effects of medicines and may have unusual reactions.

How should I take Cheracol Plus (chlorpheniramine/dextromethorphan/phenylpropanolamine)?

Take chlorpheniramine/dextromethorphan/phenylpropanolamine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

To ensure that you get a correct dose, measure the liquid form of chlorpheniramine/dextromethorphan/phenylpropanolamine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Do not take more of this medication than is recommended. An overdose of this medication can cause serious harm.

Do not take chlorpheniramine/dextromethorphan/phenylpropanolamine for longer than 7 days in a row. If your symptoms do not improve, if they get worse, or if you have a fever, talk to your doctor.

Store chlorpheniramine/dextromethorphan/phenylpropanolamine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a chlorpheniramine/dextromethorphan/phenylpropanolamine overdose include dry mouth, large pupils, flushing, nausea, vomiting, hyperactivity, or hallucinations.

What should I avoid while taking Cheracol Plus (chlorpheniramine/dextromethorphan/phenylpropanolamine)?

Use caution when driving, operating machinery, or performing other hazardous activities. Chlorpheniramine/dextromethorphan/phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking chlorpheniramine/dextromethorphan/phenylpropanolamine.

Cheracol Plus (chlorpheniramine/dextromethorphan/phenylpropanolamine) side effects

Serious side effects are unlikely to occur. Stop taking chlorpheniramine/dextromethorphan/phenylpropanolamine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take chlorpheniramine/dextromethorphan/phenylpropanolamine and talk to your doctor or try another similar medication if you experience

• 
  

  dryness of the eyes, nose, and mouth;

  
  


• 
  

  drowsiness or dizziness;

  
  


• 
  

  blurred vision;

  
  


• 
  

  difficulty urinating; or

  
  


• 
  

  excitation in children.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Cheracol Plus (chlorpheniramine/dextromethorphan/phenylpropanolamine)?

Do not take chlorpheniramine/dextromethorphan/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking chlorpheniramine/dextromethorphan/phenylpropanolamine without first talking to your doctor or pharmacist. Other medications may also contain chlorpheniramine, dextromethorphan, phenylpropanolamine, or other similar drugs. You may accidentally take too much of these medicines.

Chlorpheniramine/dextromethorphan/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if chlorpheniramine/dextromethorphan/phenylpropanolamine is taken with any of these medications.

Drugs other than those listed here may also interact with chlorpheniramine/dextromethorphan/phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Cheracol Plus resources

• Cheracol Plus Drug Interactions
• Cheracol Plus Support Group
• 0 Reviews for Cheracol Plus - Add your own review/rating

Compare Cheracol Plus with other medications

• Cold Symptoms

Where can I get more information?

• Your pharmacist has additional information about chlorpheniramine/dextromethorphan/phenylpropanolamine written for health professionals that you may read.

What does my medication look like?

Many formulations of chlorpheniramine/dextromethorphan/phenylpropanolamine are available over-the-counter. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Guaifenesin/Pseudoephedrine Controlled-Release Capsules

Pronunciation: gwye-FEN-ah-sin/sue-do-eh-FED-rin
Generic Name: Guaifenesin/Pseudoephedrine
Brand Name: Examples include Entex PSE and Nalex CR

Guaifenesin/Pseudoephedrine Controlled-Release Capsules are used for:

Relieving congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Guaifenesin/Pseudoephedrine Controlled-Release Capsules are a decongestant and expectorant combination. It works by constricting blood vessels, reducing swelling in the nasal passages, and thinning and loosening mucus in the airway. This allows you to breathe more easily and makes coughs more productive.

Do NOT use Guaifenesin/Pseudoephedrine Controlled-Release Capsules if:

• you are allergic to any ingredient in Guaifenesin/Pseudoephedrine Controlled-Release Capsules


• you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)


• you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Guaifenesin/Pseudoephedrine Controlled-Release Capsules:

Some medical conditions may interact with Guaifenesin/Pseudoephedrine Controlled-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a fast, slow, or irregular heartbeat


• if you have a history of adrenal gland problems (eg, tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, an enlarged prostate, seizures, or an overactive thyroid


• if you have chronic cough

Some MEDICINES MAY INTERACT with Guaifenesin/Pseudoephedrine Controlled-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), COMT inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Guaifenesin/Pseudoephedrine Controlled-Release Capsules's side effects


• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased


• Bromocriptine because the risk of its side effects may be increased by Guaifenesin/Pseudoephedrine Controlled-Release Capsules


• Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Guaifenesin/Pseudoephedrine Controlled-Release Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Guaifenesin/Pseudoephedrine Controlled-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Guaifenesin/Pseudoephedrine Controlled-Release Capsules:

Use Guaifenesin/Pseudoephedrine Controlled-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Guaifenesin/Pseudoephedrine Controlled-Release Capsules by mouth with or without food.


• Take Guaifenesin/Pseudoephedrine Controlled-Release Capsules with a full glass of water (8 oz/240 mL) unless your doctor tells you otherwise.


• If you miss a dose of Guaifenesin/Pseudoephedrine Controlled-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Guaifenesin/Pseudoephedrine Controlled-Release Capsules.

Important safety information:

• Guaifenesin/Pseudoephedrine Controlled-Release Capsules may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Guaifenesin/Pseudoephedrine Controlled-Release Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not take appetite suppressants while you are taking Guaifenesin/Pseudoephedrine Controlled-Release Capsules without checking with your doctor.


• Guaifenesin/Pseudoephedrine Controlled-Release Capsules has pseudoephedrine in it. Before you start any new medicine, check the label to see if it has pseudoephedrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.


• Guaifenesin/Pseudoephedrine Controlled-Release Capsules may interfere with certain lab test results. Make sure that all of your doctors and lab personnel know that you are taking Guaifenesin/Pseudoephedrine Controlled-Release Capsules.


• Tell your doctor or dentist that you take Guaifenesin/Pseudoephedrine Controlled-Release Capsules before you receive any medical or dental care, emergency care, or surgery.


• Use Guaifenesin/Pseudoephedrine Controlled-Release Capsules with caution in the ELDERLY; they may be more sensitive to its effects.


• Caution is advised when using Guaifenesin/Pseudoephedrine Controlled-Release Capsules in CHILDREN; they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Guaifenesin/Pseudoephedrine Controlled-Release Capsules, contact your doctor. You will need to discuss the benefits and risks of using Guaifenesin/Pseudoephedrine Controlled-Release Capsules while pregnant. It is not known if Guaifenesin/Pseudoephedrine Controlled-Release Capsules are found in breast milk. Do not breast-feed while taking Guaifenesin/Pseudoephedrine Controlled-Release Capsules.

Possible side effects of Guaifenesin/Pseudoephedrine Controlled-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Guaifenesin/Pseudoephedrine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Guaifenesin/Pseudoephedrine Controlled-Release Capsules:

Store Guaifenesin/Pseudoephedrine Controlled-Release Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Guaifenesin/Pseudoephedrine Controlled-Release Capsules out of the reach of children and away from pets.

General information:

• If you have any questions about Guaifenesin/Pseudoephedrine Controlled-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.


• Guaifenesin/Pseudoephedrine Controlled-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Guaifenesin/Pseudoephedrine Controlled-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Guaifenesin/Pseudoephedrine resources

• Guaifenesin/Pseudoephedrine Side Effects (in more detail)
• Guaifenesin/Pseudoephedrine Use in Pregnancy & Breastfeeding
• Drug Images
• Guaifenesin/Pseudoephedrine Drug Interactions
• Guaifenesin/Pseudoephedrine Support Group
• 58 Reviews for Guaifenesin/Pseudoephedrine - Add your own review/rating

Compare Guaifenesin/Pseudoephedrine with other medications

• Cough and Nasal Congestion

Mirtazapina Farmoz

Mirtazapina Farmoz may be available in the countries listed below.

Ingredient matches for Mirtazapina Farmoz

Mirtazapine

Mirtazapine is reported as an ingredient of Mirtazapina Farmoz in the following countries:

• Portugal

International Drug Name Search

Rafocilina

Rafocilina may be available in the countries listed below.

Ingredient matches for Rafocilina

Ofloxacin

Ofloxacin is reported as an ingredient of Rafocilina in the following countries:

• Argentina

International Drug Name Search

Proterine

Proterine may be available in the countries listed below.

Ingredient matches for Proterine

Isoxsuprine

Isoxsuprine hydrochloride (a derivative of Isoxsuprine) is reported as an ingredient of Proterine in the following countries:

• Indonesia

International Drug Name Search

Bumex Injection

Generic Name: bumetanide (Injection route)

bue-MET-a-nide

Injection route(Solution)

Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient's needs .

Commonly used brand name(s)

In the U.S.

• Bumex

Available Dosage Forms:

• Solution

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Diuretic, Loop

Uses For Bumex

Bumetanide belongs to a group of medicines called loop diuretics or "water pills." Bumetanide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine .

This medicine is available only with your doctor's prescription .

Before Using Bumex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of bumetanide injection in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of bumetanide injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney or heart problems, which may require an adjustment of dosage in patients receiving bumetanide injection .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Arsenic Trioxide


• Bepridil


• Digitoxin


• Dofetilide


• Droperidol


• Ketanserin


• Levomethadyl


• Lithium


• Metolazone


• Sotalol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alacepril


• Apazone


• Aspirin


• Benazepril


• Bromfenac


• Captopril


• Celecoxib


• Cilazapril


• Delapril


• Dibekacin


• Diclofenac


• Diflunisal


• Enalaprilat


• Enalapril Maleate


• Etodolac


• Fenoprofen


• Flurbiprofen


• Fosinopril


• Germanium


• Ginseng


• Gossypol


• Ibuprofen


• Ibuprofen Lysine


• Imidapril


• Indomethacin


• Kanamycin


• Ketoprofen


• Ketorolac


• Licorice


• Lisinopril


• Magnesium Salicylate


• Meclofenamate


• Mefenamic Acid


• Meloxicam


• Moexipril


• Nabumetone


• Naproxen


• Neomycin


• Nepafenac


• Oxaprozin


• Pentopril


• Perindopril


• Piroxicam


• Quinapril


• Ramipril


• Salicylic Acid


• Salsalate


• Spirapril


• Streptomycin


• Sulindac


• Temocapril


• Tolmetin


• Trandolapril


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anuria (not able to form urine) or


• Liver disease, severe (e.g., hepatic coma)—Should not use in patients with these conditions .

• Dehydration or


• Gout or


• Hearing problems or


• Hyperuricemia (high uric acid in the blood) or


• Hypocalcemia (low calcium in the blood) or


• Hypokalemia (low potassium in the blood) or


• Hypomagnesemia (low magnesium in the blood) or


• Hypovolemia (low blood volume) or


• Thrombocytopenia (low platelets in the blood)—Use with caution. This medicine may make these conditions worse .

• Diabetes—This medicine may increase the amount of sugar in the blood .

• Kidney disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body .

Proper Use of Bumex

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins .

Precautions While Using Bumex

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to another medicine that works the same way. If you have any concerns about this, talk to your doctor .

Bumex Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Abdominal pain


• blurred vision


• confusion


• decreased urine output


• dizziness


• drowsiness


• dry mouth


• fast or irregular heartbeat


• flushed, dry skin


• fruit-like breath odor


• headache


• increased hunger


• increased thirst


• increased urination


• irritability


• joint pain, stiffness, or swelling


• loss of appetite


• loss of mental alertness


• lower back, side, or stomach pain


• mood or mental changes


• muscle pain or cramps


• nausea or vomiting


• numbness or tingling in the hands, feet, or lips


• shortness of breath


• sweating


• swelling of face, hands, feet, ankles, or lower legs


• troubled breathing


• unexplained weight loss


• unusual tiredness or weakness


• weak pulse

Rare

• Agitation


• back pain


• black, tarry stools


• bleeding gums


• blood in the urine or stools


• chest pain


• convulsions (seizures)


• deep or fast breathing with dizziness


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• fever


• hallucinations


• hives


• increase in heart rate


• increased blood pressure


• numbness of feet, hands, and around the mouth


• pinpoint red spots on the skin


• rapid breathing


• stiff neck


• sunken eyes


• trembling, jerking of hands


• unusual bleeding or bruising


• weight gain


• wrinkled skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Difficulty breathing


• pain in chest, groin, or legs, especially the calves


• severe, sudden headache


• slurred speech


• sudden loss of coordination


• sudden, severe weakness or numbness in the arm or leg


• sudden, unexplained shortness of breath


• tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area


• unusual drowsiness, dullness, or feeling of sluggishness


• vision changes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

• Decreased interest in sexual intercourse


• diarrhea


• difficulty with moving


• ear discomfort


• feeling of constant movement of self or surroundings


• inability to have or keep an erection


• itching skin


• loss in sexual ability, desire, drive, or performance


• muscle or bone pain


• muscle stiffness


• nipple tenderness


• pain, swelling, or redness in joints


• rash


• sensation of spinning


• shorter than usual time to ejaculation of semen


• trouble with hearing


• upset stomach

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Bumex Injection side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Bumex Injection resources

• Bumex Injection Side Effects (in more detail)
• Bumex Injection Use in Pregnancy & Breastfeeding
• Drug Images
• Bumex Injection Drug Interactions
• Bumex Injection Support Group
• 1 Review for Bumex Injection - Add your own review/rating

Compare Bumex Injection with other medications

• Ascites
• Edema
• Pulmonary Edema

rimabotulinumtoxinb Intramuscular

rim-a-bot-ue-LYE-num-tox-in-bee

Intramuscular route(Injectable)

The effects of rimabotulinumtoxinB and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults, particularly in those patients who have underlying conditions that would predispose them to these symptoms. Cases of spread of effect have occurred at doses comparable to those used to treat cervical dystonia and at lower doses .

Commonly used brand name(s)

In the U.S.

• Myobloc

Available Dosage Forms:

• Solution

Therapeutic Class: Cervical Agent

Pharmacologic Class: Neuromuscular Blocker, Non-Depolarizing

Uses For rimabotulinumtoxinb

RimabotulinumtoxinB is used to treat the abnormal head position and neck pain that result from cervical dystonia (severe muscle spasms of the neck). RimabotulinumtoxinB is a botulinum toxin B product. It works on the nervous system to relax the muscles.

RimabotulinumtoxinB is injected into the muscles that are affected. Depending on your condition, more than one treatment may be required.

rimabotulinumtoxinb is available only with your doctor's prescription and will be administered by your doctor.

Before Using rimabotulinumtoxinb

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rimabotulinumtoxinb, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to rimabotulinumtoxinb or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of rimabotulinumtoxinB in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rimabotulinumtoxinB in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of rimabotulinumtoxinb. Make sure you tell your doctor if you have any other medical problems, especially:

• Amyotrophic lateral sclerosis (Lou Gehrig's disease) or


• Lambert-Eaton syndrome (nerve-muscle disorder) or


• Motor neuropathy (muscle or nerve problem) or


• Myasthenia gravis (severe muscle weakness)—May cause side effects to become worse.

• Breathing problems or


• Dysarthria (trouble with speaking) or


• Dysphagia (trouble with swallowing) or


• Dysphonia (voice problem) or


• Ptosis (droopy eyelid) or


• Urinary incontinence (problems passing urine)—Use with caution. May make these conditions worse.

• Infection at the injection site—Should not be used in patients with this condition.

Proper Use of rimabotulinumtoxinb

Your doctor will give you rimabotulinumtoxinb in a hospital or clinic. rimabotulinumtoxinb is given as a shot into one of your muscles.

Your doctor will only use rimabotulinumtoxinB (Myobloc®) to treat your condition. Other botulinum toxin products may not work the same way and require a different dose.

Precautions While Using rimabotulinumtoxinb

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Serious muscle reactions have occurred within hours to weeks after receiving rimabotulinumtoxinb. If you start to have muscle weakness or trouble with swallowing, talking, or breathing, call your doctor right away. In some situations, these problems could be life-threatening and may require treatment in a hospital or clinic.

rimabotulinumtoxinb may make your muscles weak and cause vision problems. Avoid driving, using machines, or doing anything else that could be dangerous if you feel weak or are not able to see well.

One part of rimabotulinumtoxinb is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made of human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the manufacture of these medicines. Although the risk is low, talk with your doctor if you have concerns.

rimabotulinumtoxinb Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Difficulty with swallowing


• infection


• neck pain


• uncontrolled twisting movements of the neck

Rare

• Difficulty with breathing or speaking


• muscle weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach


• back pain


• belching


• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site


• cough


• difficulty with moving


• dizziness


• dry mouth


• flu-like syndrome


• headache


• heartburn or indigestion


• lack or loss of strength or energy


• muscle pain, stiffness, or weakness


• nausea


• pain, swelling, or redness in the joints


• stomach discomfort, upset, or pain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More rimabotulinumtoxinb Intramuscular resources

• Rimabotulinumtoxinb Intramuscular Side Effects (in more detail)
• Rimabotulinumtoxinb Intramuscular Use in Pregnancy & Breastfeeding
• Rimabotulinumtoxinb Intramuscular Drug Interactions
• Rimabotulinumtoxinb Intramuscular Support Group
• 0 Reviews for Rimabotulinumtoxinb Intramuscular - Add your own review/rating

Compare rimabotulinumtoxinb Intramuscular with other medications

• Cervical Dystonia
• Dystonia
• Facial Wrinkles
• Hyperhidrosis